Fulham and Wales midfielder Simon Davies has retired from international football.
The 30-year-old Fulham player won 58 caps for Wales, scoring six goals, after making his debut in 2001.
The Football Association of Wales said Davies had decided to concentrate on club football after struggling with a foot injury for the past 18 months.
Davies has slipped down the Wales midfield pecking order due to emergence of Aaron Ramsey, David Edwards, Jack Collison, Joe Ledley and Andy King.
But the news will be a blow for Wales boss John Toshack, who only last week spoke about the importance of senior players such as Davies as Wales attempt to qualify for Euro 2012.
Davies, who made his Wales bow debut in a World Cup qualifier against Ukraine in March 2001, last played for Wales in the friendly loss to Sweden in March but that had been his first appearance in almost a year because of injury.
And Davies, who captained Wales in their 2-0 defeat by Germany in April 2009, even admitted to BBC Sport almost exactly 12 months ago that he considered quitting Wales.
"I did initially think after this campaign I'd have a look and see about retiring from Wales," Davies said last year.
Archive - Simon Davies most famous Wales goal against Italy in October 2002
"It gets harder and harder because the Premier League is so demanding.
"It is sometimes difficult to go away with Wales when you see the other lads having a few days off recharging their batteries."
But Davies deciding to call time on his international career is the latest in a long line of high-profile experienced Wales players to retireme since previous boss Mark Hughes quit.
Gary Speed, Robbie Savage, Mark Delaney, John Hartson, Mark Pembridge, Andy Melville and Ryan Giggs have all quit Wales since Hughes left to take over at Blackburn in 2004.
But Toshack is in the middle of a Wales rebuilding process with the country's promising youngsters.
And Davies was one of the senior Welsh players criticised following Wales' disappointing World Cup qualifying defeat to an average Finland side in Cardiff in March last year, a loss that made 2010 World Cup qualification virtually impossible.
Arsenal playmaker Ramsey, West Ham sensation Collison, Celtic new boy Ledley, Wolverhampton Wanderers youngster Edwards and King of Leicester are ahead of Davies in Toshack's pecking order.
So instead of Davies, a star of Fulham's charge to last season's Europa Cup final, being a Wales squad player so the Haverfordwest-born player informed the Welsh FA of his decision to retire.
Wales begin their preparations for their Euro 2012 qualifying campaign, which begins in Montenegro on 3 September, with a friendly against Luxembourg in Llanelli on Wednesday.
A Welsh FA statement read: "The FAW would like to take the opportunity of thanking Simon for his service and wishes him well for the forthcoming season with Fulham."