Fulham boss Claudio Ranieri returns to Stamford Bridge on Sunday as Fulham kick off Derby Day with a clash against west London rivals Chelsea, live on Sky Sports.
Ranieri managed Chelsea between 2000-2004, reaching the semi-finals of the Champions League and laying the platform for future success at the club.
He made a winning start at Fulham last weekend as Aleksandar Mitrovic scored twice in a 3-2 victory over Southampton.
"When you win, everything changes," said Ranieri. "The players come here happier and that is normal. But now we have to forget and think about Chelsea.
Chelsea will be looking to bounce back after suffering their first defeat of the season against Tottenham last weekend.
They made 10 changes on Thursday as they beat PAOK 4-0 in the Europa League, but Maurizio Sarri is set to revert to his first-choice line-up against Fulham.
"In the last match the problem was the team, not one or two players," he said.
Eden Hazard is pushing to return after missing the win over PAOK with an ankle injury, but Olivier Giroud's two-goal performance may not dislodge Alvaro Morata as first-choice striker, particularly as the Frenchman appeared to suffer a knock in the second half.
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Chelsea are unbeaten the last 16 times they have faced Fulham in the league, and have lost only one of their 26 Premier League matches against the Cottagers (W15, D10).
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Fulham's last win over Chelsea came in March 2006, when Luis Boa Morte's goal gave them a 1-0 win at Craven Cottage.
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This is the first Premier League encounter between Chelsea and Fulham since March 2014, when current Fulham player Andre Schurrle scored a hat-trick for the Blues in a 3-1 win.
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Fulham have won just one of their 24 away top-flight matches against Chelsea (D9 L14), a 2-1 victory in March 1964 under manager Bedford Jezzard.
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This is the first Premier League encounter between Chelsea and Fulham since March 2014, when current Fulham player Andre Schurrle scored a hat-trick for the Blues in a 3-1 win.
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Fulham ended a run of seven consecutive defeats in all competitions with a 3-2 win over Southampton last weekend.
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They have picked up just one point from a possible 21 in away games this season.
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Fulham are the only one of the 92 league sides in English football yet to keep a clean sheet this season - and have conceded at least two goals in 11 of their 13 league games.
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They have conceded 18 away goals, more than any other team in the Premier League this term.
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Fulham have lost all three of their London derbies in the Premier League this season, with an aggregate score of 10-2.
Chelsea have picked up just one point from the last six available and suffered their first league defeat of the season at Tottenham last weekend.
They haven't gone three Premier League games without a win since September 2016.
The Blues are unbeaten at Stamford Bridge since April but are aiming to keep consecutive home league clean sheets for the first time in 2018.
Chelsea have won both of their home London derbies this season - beating Arsenal in August and Crystal Palace in November.
Chelsea's next home goal will be their 1,000th at Stamford Bridge in the Premier League.