Fulham will be looking to bring an end to their winless run when they take on Southampton at St Mary's on Saturday afternoon.
The Cottagers' fate was confirmed with defeat at home to Burnley on Monday, while Southampton beat Crystal Palace last time out to climb up to 14th place.
Despite a supposed upturn in performances over the past few months, Fulham have now taken just one point from their last seven Premier League games.
That solitary point did come away at Arsenal, and Scott Parker's men also won away to Liverpool two months ago, but there can be no complaints regarding their relegation.
The Cottagers quite simply have not been good enough over the course of the campaign, and the 2-0 loss against Burnley at Craven Cottage this week was the final nail in the coffin.
Fulham knew that only a win would do, but goals from Ashley Westwood and Chris Wood in the final 10 minutes of the first half sealed a 2-0 victory for Sean Dyche's men.
In doing so, it means that the bottom three places have been wrapped up in the Premier League with at least three games still to play for the first time ever.
Fulham are now effectively playing for pride when they travel to Southampton and Manchester United, before concluding their season at home to Newcastle United.
A good omen for the South London side, though, is that they have avoided defeat in their next game on the two previous occasions that their Premier League relegation was confirmed.
Like their opponents, Southampton also have little to play for in the final week of the season as they are essentially jostling for position in the lowest reaches of the division.
The Saints led the way at the top of the Premier League just six months ago, but their form has plummeted since then and relegation was a concern at one stage.
Following a run of five defeats and a draw in the space of six games, however, Ralph Hasenhuttl's charges beat Palace fairly resoundingly on Tuesday to get back on track.
Danny Ings scored twice on his return from injury and Che Adams was also on target after Christian Benteke had given Palace an early lead on the South Coast.
Not since before Christmas have Southampton won back-to-back league games, but they will consider this a real chance to do exactly that and potentially climb a place into 14th.
The sides played out a goalless draw at Craven Cottage on Boxing Day, making it just one defeat in eight Premier League meetings for Southampton in this fixture.
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Southampton have lost just one of the past eight Premier League meetings, winning three and drawing four.
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Fulham have only won one of their past 30 league visits to Southampton (D8, L21).
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There has only been one away win in 15 Premier League encounters.
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Fulham have only earned one point from their seven most recent matches.
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They have failed to score in 17 league games this season; only Sheffield United have fared worse.
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Fulham have opened the scoring in nine Premier League away matches this season but won just three of those.
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Top scorer Bobby De Cordova-Reid is without a goal in his past 12 appearances.
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All three of Aleksandar Mitrovic's Premier League goals for Fulham this season have come away from home.
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Southampton have won once in five matches, drawing one and losing three.
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They have earned the fewest points (14) and conceded the most goals (43) in the Premier League this calendar year.
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Ralph Hasenhuttl's side have lost 13 of 17 league games since beating Liverpool in January.
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Saints have only kept one clean sheet in their last 18 league matches.
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They have lost just three of their last 43 Premier League home fixtures against sides starting the day in the relegation zone.