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Ruben Loftus-Cheek cannot face his parent club so will miss out for Fulham, but Mario Lemina and Andre Zambo Anguissa would have been expected to start in the middle anyway.
Terence Kongolo, Marek Rodak and Tom Cairney are all out for the long term, while Kenny Tete's involvement is uncertain as he aims to recover from a bout of COVID-19.
The bulk of the team who started in the draw at the Emirates should retain their places here, but a frustrated Aleksandar Mitrovic will hope to come into Parker's thinking if Ivan Cavaleiro finds his spot in peril.
Fulham possible starting lineup:
Areola; Aina, Andersen, Adarabioyo, Robinson; Decordova-Reid, Lemina, Zambo Anguissa, Lookman; Maja, Mitrovic
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Chelsea boss Tuchel is hopeful that Mateo Kovacic will return from a thigh problem in time to face the Cottagers, but the midfielder would almost certainly feature as a substitute if he is cleared to play.
The hosts have no selection concerns otherwise, but rotation should be on the cards ahead of next week's second leg, potentially starting with Reece James and Kurt Zouma earning recalls to the defence.
Kai Havertz and Hakim Ziyech are both in contention for starts in the final third, while Tammy Abraham and Olivier Giroud can feel confident of earning some long-awaited game time, albeit probably from the bench.
Chelsea possible starting lineup:
Mendy; Zouma, Rudiger, Christensen; James, Jorginho, Kante, Alonso; Ziyech, Mount; Havertz
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Source Ben Knapton at SportsMole